Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c

Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c

Under conditions of obesity and insulin resistance, the serine/threonine protein kinase Akt/PKB is required for lipid accumulation in liver. Two forkhead transcription factors, FoxA2 and FoxO1, have been suggested to function downstream of and to be negatively regulated by Akt and are proposed as ke...

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Bibliographic Details
Main Authors: Wan, Min (Author), Leavens, Karla F (Author), Saleh, Danish (Author), Easton, Rachael M (Author), Guertin, David A. (Contributor), Peterson, Timothy R (Author), Kaestner, Klaus H. (Author), Sabatini, David M (Author), Birnbaum, Morris J (Author), Sabatini, David (Author), Peterson, Timothy Richard (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor), Peterson, Timothy R. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-10T15:46:39Z.
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