Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

Toll-like receptor (TLR) signaling plays a critical role in innate and adaptive immune responses and must be tightly controlled. TLR4 uses LPS binding protein, MD-2, and CD14 as accessories to respond to LPS. We therefore investigated the presence of an analagous soluble cofactor that might assist i...

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Bibliographic Details
Main Authors: Park, Boyoun (Author), Buti, Ludovico (Author), Lee, Sungwook (Author), Matsuwaki, Takashi (Author), Spooner, Eric (Author), Brinkmann, Melanie M. (Author), Nishihara, Masugi (Author), Ploegh, Hidde (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-10T18:48:15Z.
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