mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcr...

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Main Authors: Peterson, Timothy R (Author), Sengupta, Shomit S (Author), Harris, Thurl E (Author), Carpenter, Anne E. (Author), Kang, Seong A. (Contributor), Balderas, Eric (Contributor), Guertin, David A. (Author), Madden, Katherine L. (Author), Finck, Brian N (Author), Sabatini, David M (Author), Peterson, Timothy Richard (Author), Sengupta, Shomit (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Peterson, Timothy R. (Contributor), Sengupta, Shomit S. (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-10T19:02:19Z.
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