Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

The metazoan mitochondrial translation machinery is unusual in having a single tRNA[superscript Met] that fulfills the dual role of the initiator and elongator tRNA[superscript Met]. A portion of the Met-tRNA[superscript Met] pool is formylated by mitochondrial methionyl-tRNA formyltransferase (MTFM...

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Main Authors: Tucker, Elena J (Author), Hershman, Steven G (Author), Belcher-Timme, Casey A (Author), Patel, Jinal (Author), Goldberger, Olga A. (Author), Christodoulou, John (Author), Silberstein, Jonathon M (Author), McKenzie, Matthew (Author), Ryan, Michael T (Author), Compton, Alison G (Author), Jaffe, Jacob D. (Author), Carr, Steven A. (Author), Calvo, Sarah E. (Author), RajBhandary, Uttam L (Author), Thorburn, David R (Author), Mootha, Vamsi K. (Author), Koehrer, Caroline (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), RajBhandary, Uttam L. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-11T19:31:32Z.
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