Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

While the abuse of opiate drugs continues to rise, the neuroadaptations that occur with long-term drug exposure remain poorly understood. We describe here a series of chronic morphine-induced adaptations in ventral tegmental area (VTA) dopamine neurons, which are mediated via downregulation of AKT-m...

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Main Authors: Mazei-Robison, Michelle S. (Author), Koo, Ja Wook (Author), Friedman, Allyson K. (Author), Lansink, Carien S. (Author), Robison, Alfred J (Author), Vinish, Monika (Author), Krishnan, Vaishnav (Author), Kim, Seyun (Author), Siuta, Michael A (Author), Galli, Aurelio (Author), Niswender, Kevin D. (Author), Appasani, Raghu (Author), Horvath, Monika C (Author), Neve, Rachael L. (Contributor), Worley, Paul F. (Author), Snyder, Solomon H. (Author), Hurd, Yasmin L. (Author), Cheer, Joseph F. (Author), Han, Ming-Hu (Author), Russo, Scott J. (Author), Nestler, Eric J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-16T16:50:42Z.
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