Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages
Protein quality control requires careful regulation of intracellular proteolysis. For DegP, a periplasmic protease, substrates promote assembly of inactive hexamers into proteolytically active cages with 12, 18, 24, or 30 subunits. Here, we show that sensitive activation and cage assembly require co...
Main Authors: | Kim, Seokhee (Contributor), Grant, Robert A (Author), Sauer, Robert T (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Grant, Robert A. (Contributor), Sauer, Robert T. (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2014-12-16T21:18:54Z.
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Subjects: | |
Online Access: | Get fulltext |
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