Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number variants of the SNCA gene locus can cause...

Full description

Bibliographic Details
Main Authors: Flierl, Adrian (Author), Oliveira, Luís M. A. (Author), Falomir-Lockhart, Lisandro J. (Author), Mak, Sally K. (Author), Hesley, Jayne (Author), Soldner, Frank (Contributor), Arndt-Jovin, Donna J. (Author), Jaenisch, Rudolf (Contributor), Langston, J. William (Author), Jovin, Thomas M. (Author), Schüle, Birgitt (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-12-23T19:00:29Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items