Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for age-related neurodegenerative diseases, has been challenging. Here, we exploited mutation correction of iPS cells and conserved proteotoxic me...

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Main Authors: Chung, Chee Yeun (Author), Khurana, Vikram (Author), Auluck, Pavan K. (Author), Tardiff, Daniel F. (Author), Mazzulli, Joseph R. (Author), Soldner, Frank (Author), Baru, Valeriya (Author), Lou, Yali (Author), Freyzon, Yelena (Author), Cho, Sukhee (Contributor), Muffat, Julien (Author), Mitalipova, Maisam (Author), Pluth, Michael D. (Contributor), Jui, Nathan T. (Contributor), Schule, Birgitt (Author), Lippard, Stephen J. (Contributor), Tsai, Li-Huei (Contributor), Krainc, Dimitri (Author), Jaenisch, Rudolf (Contributor), Lindquist, Susan (Contributor), Mungenast, Alison (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Picower Institute for Learning and Memory (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-01-15T17:19:43Z.
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