Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer

DNA instability is an important contributor to cancer development. Previously, defects in the chromosome segregation and excessive DNA double strand breaks due to the replication or oxidative stresses were implicated in DNA instability in cancer. Here, we demonstrate that DNA instability can directl...

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Bibliographic Details
Main Authors: Yaglom, Julia A. (Author), McFarland, Christopher D. (Author), Mirny, Leonid A. (Contributor), Sherman, Michael Y. (Author)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. School of Engineering (Contributor)
Format: Article
Language:English
Published: Impact Journals, 2015-01-26T18:12:10Z.
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