Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine

Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine

Viral lethal mutagenesis is a strategy whereby the innate immune system or mutagenic pool nucleotides increase the error rate of viral replication above the error catastrophe limit. Lethal mutagenesis has been proposed as a mechanism for several antiviral compounds, including the drug candidate 5-az...

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Bibliographic Details
Main Authors: Li, Deyu (Contributor), Fedeles, Bogdan I. (Contributor), Singh, Vipender (Contributor), Peng, Chunte Sam (Contributor), Silvestre, Katherine J. (Contributor), Simi, Allison K. (Contributor), Simpson, Jeffrey H. (Contributor), Essigmann, John M. (Contributor), Tokmakoff, Andrei (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-02-05T16:54:25Z.
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