Yeast Reveal a 'Druggable' Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons

Yeast Reveal a 'Druggable' Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons

α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson's disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodege...

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Main Authors: Jui, Nathan T. (Contributor), Buchwald, Stephen Leffler (Contributor), Lindquist, Susan (Contributor), Tardiff, Daniel F. (Author), Khurana, Vikram (Author), Tambe, Mitali A. (Author), Thompson, Michelle L. (Author), Chung, Chee Yeun (Author), Kamadurai, Hari B. (Author), Kim, Hyoung Tae (Author), Lancaster, Alex K. (Author), Caldwell, Kim A. (Author), Caldwell, Guy A. (Author), Rochet, Jean-Christophe (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-02-12T19:23:03Z.
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