Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles

Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles

Aim: Two unexplored aspects for irinotecan and cisplatin (I&C) combination chemotherapy are: actively targeting both drugs to a specific diseased cell type, and delivering both drugs on the same vehicle to ensure their synchronized entry into the cell at a well-defined ratio. In this work, the a...

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Main Authors: Valencia, Pedro M (Author), Pridgen, Eric M (Author), Perea, Brian (Author), Gadde, Suresh (Author), Sweeney, Christopher (Author), Kantoff, Philip W. (Author), Bander, Neil H. (Author), Langer, Robert (Contributor), Lippard, Stephen J. (Contributor), Farokhzad, Omid C. (Contributor), Karnik, Rohit (Contributor), Valencia, Pedro M. (Contributor), Pridgen, Eric M. (Contributor)
Other Authors: MIT-Harvard Center for Cancer Nanotechnology Excellence (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Future Medicine, 2015-02-19T20:33:47Z.
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