Small RNA combination therapy for lung cancer

Small RNA combination therapy for lung cancer

MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering miRNA mimics and siRNAs to lung adenocarcinoma cells in vitro and to tumor...

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Main Authors: Tammela, Tuomas (Contributor), Xue, Wen (Contributor), Dahlman, James E. (Contributor), Sood, Sabina (Contributor), Dave, Apeksha (Contributor), Cai, Wenxin (Contributor), Chirino, Leilani M. (Contributor), Yang, Gillian R. (Contributor), Bronson, Roderick T. (Author), Crowley, Denise G. (Contributor), Sahay, Gaurav (Contributor), Anderson, Daniel Griffith (Contributor), Khan, Omar Fizal (Author), Schroeder, Avraham Dror (Author), Langer, Robert S (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Khan, Omar F. (Contributor), Schroeder, Avi (Contributor), Langer, Robert (Contributor), Jacks, Tyler E. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-03-03T20:08:19Z.
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