Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

Epidermal growth factor receptors (ErbB1-4) are oncogenic receptor tyrosine kinases (RTKs) that regulate diverse cellular processes. In this study, we combine measurement and mathematical modeling to quantify phospho-turnover at ErbB receptors in human cells and to determine the consequences for sig...

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Bibliographic Details
Main Authors: Kleiman, Laura B (Author), Maiwald, Thomas (Author), Conzelmann, Holger (Author), Lauffenburger, Douglas A (Author), Sorger, Peter K (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Kleiman, Laura B. (Contributor), Lauffenburger, Douglas A. (Contributor), Sorger, Peter K. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-03-04T19:13:41Z.
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