Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use a chemical genetics screen to identify direct substrates of AMPK in human cells. We find that AMPK phos...

Full description

Bibliographic Details
Main Authors: Banko, Max R (Author), Allen, Jasmina J (Author), Schaffer, Bethany E (Author), Wilker, Erik W (Author), Tsou, Peiling (Author), White, Jamie L (Author), Villen, Judit (Author), Wang, Beatrice (Author), Kim, Sara R. (Contributor), Sakamoto, Kei (Author), Gygi, Steven P. (Author), Cantley, Lewis C. (Author), Yaffe, Michael B (Author), Shokat, Kevan M (Author), Brunet, Anne (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Yaffe, Michael B. (Contributor), Wilker, Erik W. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-03-05T16:59:39Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items