Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library

Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library

Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we developed a method for combining structure-based computational protein design wi...

Full description

Bibliographic Details
Main Authors: Lippow, Shaun M. (Author), Moon, Tae Seok (Contributor), Basu, Subhayu (Author), Yoon, Sang-Hwal (Contributor), Li, Xiazhen (Author), Chapman, Brad A. (Author), Robison, Keith (Author), Lipovšek, Daša (Author), Prather, Kristala L. Jones (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-03-17T16:10:57Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items