Synthetic shuffling and in vitro selection reveal the rugged adaptive fitness landscape of a kinase ribozyme
The relationship between genotype and phenotype is often described as an adaptive fitness landscape. In this study, we used a combination of recombination, in vitro selection, and comparative sequence analysis to characterize the fitness landscape of a previously isolated kinase ribozyme. Point muta...
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory Press,
2015-03-27T16:14:25Z.
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| Subjects: | |
| Online Access: | Get fulltext |