Tight Coordination of Protein Translation and Heat Shock Factor 1 Activation Supports the Anabolic Malignant State

Tight Coordination of Protein Translation and Heat Shock Factor 1 Activation Supports the Anabolic Malignant State

The ribosome is centrally situated to sense metabolic states, but whether its activity, in turn, coherently rewires transcriptional responses is unknown. Here, through integrated chemical-genetic analyses, we found that a dominant transcriptional effect of blocking protein translation in cancer cell...

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Main Authors: Santagata, S. (Author), Mendillo, Marc L. (Author), Subramanian, A. (Author), Perley, C. C. (Author), Roche, S. P. (Author), Wong, B. (Author), Narayan, Rajiv (Author), Kwon, H. (Author), Golub, Todd R. (Author), Porco, J. A. (Author), Whitesell, L. (Author), Lindquist, Susan (Contributor), Tang, Yun-Chi (Author), Koeva, Martina I (Author), Amon, Angelika B (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Tang, Yun-chi (Contributor), Koeva, Martina I. (Contributor), Amon, Angelika B. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-03-27T16:25:19Z.
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