Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

Overexpression of transcription factors has been used to directly reprogram somatic cells into a range of other differentiated cell types, including multipotent neural stem cells (NSCs), that can be used to generate neurons and glia. However, the ability to maintain the NSC state independent of the...

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Main Authors: Cassady, John P. (Contributor), D'Alessio, Ana C. (Author), Sarkar, Sovan (Author), Fan, Zi Peng (Contributor), Ganz, Kibibi (Author), Roessler, Reinhard (Author), Sur, Mriganka (Contributor), Young, Richard A (Author), Jaenisch, Rudolf (Contributor), Dani, Vardhan (Contributor), Young, Richard A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-03-31T15:37:32Z.
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