DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We identify DEPTOR as an mTOR-interacting protein whose expression is negatively regulated by mTORC1 and mTORC2. Loss of DEPTOR activates S6K1, Akt, and SGK1, promotes cell growth and survival, and activates mTORC1 and...

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Bibliographic Details
Main Authors: Peterson, Timothy R. (Contributor), Laplante, Mathieu (Author), Thoreen, Carson C. (Contributor), Sancak, Yasemin (Contributor), Kang, Seong A. (Contributor), Kuehl, W. Michael (Author), Gray, Nathanael S. (Contributor), Sabatini, David M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Laplante, Mathieu (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2015-03-31T20:44:26Z.
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