Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is ne...

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Main Authors: Depoil, David (Author), Martinelli, Roberta (Author), Judokusumo, Edward (Author), Carmona, Guillaume (Contributor), Kam, Lance C. (Author), Carman, Christopher V. (Author), Burkhardt, Janis K. (Author), Dustin, Michael L. (Author), Gertler, Frank (Contributor), Kumari, Sudha (Author), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Kumari, Sudha Kumari (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd., 2015-04-02T18:02:01Z.
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