The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

NAD[superscript +] is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD[superscript +] levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD[superscript +] levels results in a further reduction i...

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Main Authors: Mouchiroud, Laurent (Author), Houtkooper, Riekelt H (Author), Moullan, Norman (Author), Katsyuba, Elena (Author), Ryu, Dongryeol (Author), Canto, Carles (Author), Mottis, Adrienne (Author), Jo, Young-Suk (Author), Viswanathan, Mohan (Contributor), Schoonjans, Kristina (Author), Auwerx, Johan (Author), Guarente, Leonard Pershing (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-04-07T17:38:20Z.
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