Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Sirtuin 1 (Sirt1), a NAD[superscript +]-regulated deacetylase with numerous known positive effects on cellular and whole-body metabolism, is expressed in the renal cortex and medulla. It is known to have protective effects against age-related disease, including diabetes. Here we investigated the pro...

Full description

Bibliographic Details
Main Authors: Hasegawa, Kazuhiro (Author), Wakino, Shu (Author), Simic, Petra (Contributor), Sakamaki, Yusuke (Author), Minakuchi, Hitoshi (Author), Fujimura, Keiko (Author), Hosoya, Kozi (Author), Komatsu, Motoaki (Author), Kaneko, Yuka (Author), Kanda, Takeshi (Author), Kubota, Eiji (Author), Tokuyama, Hirobumi (Author), Itoh, Hiroshi (Author), Guarente, Leonard Pershing (Contributor), Hayashi, Koichi 1967- (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-07T18:29:07Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items