Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions

Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions

Described is the development and application of a versatile semisynthetic strategy, based on a combination of sortase-mediated coupling and tetrazine ligation chemistry, which can be exploited for the efficient incorporation of tunable functionality into chimeric recombinant proteins. To demonstrate...

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Bibliographic Details
Main Authors: Krueger, Andrew T. (Contributor), Kroll, Carsten (Contributor), Sanchez, Edgar (Contributor), Imperiali, Barbara (Contributor), Griffith, Linda G (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Griffith, Linda G. (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2015-04-09T17:18:19Z.
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