Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents

Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents

A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.

Bibliographic Details
Main Authors: Zhu, Ye (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-04-09T18:29:18Z.
Subjects:
Article
Online Access:Get fulltext
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100 1 0 |a Zhu, Ye  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Buchwald, Stephen Leffler  |e contributor 
100 1 0 |a Zhu, Ye  |e contributor 
700 1 0 |a Buchwald, Stephen Leffler  |e author 
245 0 0 |a Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents 
260 |b American Chemical Society (ACS),   |c 2015-04-09T18:29:18Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/96508 
520 |a A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines. 
520 |a National Institutes of Health (U.S.) (Award GM58160) 
520 |a Amgen Inc. 
546 |a en_US 
655 7 |a Article 
773 |t Journal of the American Chemical Society 

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