Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites

N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins interacting with METTL3, a component of the methyltransferase complex, and show that three of them (WTAP, METTL14, and KIAA1429) are require...

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Main Authors: Schwartz, Schraga (Author), Mumbach, Maxwell R (Author), Jovanovic, Marko (Author), Wang, Tim (Contributor), Maciag, Karolina (Author), Bushkin, G. Guy (Author), Mertins, Philipp (Author), Ter-Ovanesyan, Dmitry (Author), Habib, Naomi (Author), Cacchiarelli, Davide (Author), Sanjana, Neville E (Author), Freinkman, Elizaveta (Author), Pacold, Michael E. (Author), Satija, Rahul (Author), Hacohen, Nir (Author), Zhang, Feng (Contributor), Regev, Aviv (Contributor), Mikkelsen, Tarjei Sigurd 1978- (Author), Carr, Steven A (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Carr, Steven A. (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-04-17T17:28:08Z.
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