A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

Treatment of cells with brefeldin A (BFA) blocks secretory vesicle transport and causes a collapse of the Golgi apparatus. To gain more insight into the cellular mechanisms mediating BFA toxicity, we conducted a genome-wide haploid genetic screen that led to the identification of the small G protein...

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Main Authors: Reiling, Jan H. (Contributor), Olive, Andrew J. (Author), Sanyal, Sumana (Contributor), Carette, Jan E. (Author), Brummelkamp, Thijn R. (Author), Starnbach, Michael N. (Author), Ploegh, Hidde (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-21T18:16:32Z.
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