Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single-cell RNA sequencing (RNA-seq) to profile 430 cells from five primary glioblastomas, which we f...

Full description

Bibliographic Details
Main Authors: Patel, A. P. (Author), Tirosh, I. (Author), Trombetta, J. J. (Author), Gillespie, S. M. (Author), Wakimoto, H. (Author), Cahill, D. P. (Author), Nahed, B. V. (Author), Curry, W. T. (Author), Martuza, R. L. (Author), Louis, D. N. (Author), Rozenblatt-Rosen, O. (Author), Suva, M. L. (Author), Bernstein, Bradley E. (Author), Regev, Aviv (Contributor), Shalek, Alex K. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-04-22T17:59:06Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items