Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

The target of rapamycin (TOR) is a critical regulator of growth, survival, and energy metabolism. The allosteric TORC1 inhibitor rapamycin has been used extensively to elucidate the TOR related signal pathway but is limited by its inability to inhibit TORC2. We used an unbiased cell proliferation as...

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Bibliographic Details
Main Authors: Liu, Qingsong (Author), Ren, Tao (Author), Fresques, Tara (Author), Oppliger, Wolfgang (Author), Niles, Brad J. (Author), Hur, Wooyoung (Author), Hall, Michael N. (Author), Powers, Ted (Author), Gray, Nathanael S. (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-04-23T14:56:38Z.
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