Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the life span of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased insulin sensitivity, and it therefore is surprising that chronic rapamycin treatme...
Main Authors: | Lamming, Dudley W. (Contributor), Ye, Lan (Author), Astle, Clinton M. (Author), Baur, Joseph A. (Author), Harrison, David E. (Author), Sabatini, David (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor) |
Format: | Article |
Language: | English |
Published: |
Wiley Blackwell,
2015-04-23T16:59:47Z.
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Subjects: | |
Online Access: | Get fulltext |
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