Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates organismal growth in response to many environmental cues, including nutrients and growth factors. Cell-based studies showed that mTORC1 senses amino acids through the RagA-D family of GTPases (also known as RRAGA, B, C and D),...

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Main Authors: Efeyan, Alejo (Author), Zoncu, Roberto (Author), Chang, Steven (Author), Gumper, Iwona (Author), Snitkin, Harriet (Author), Kirak, Oktay (Author), Sabatini, David D. (Author), Wolfson, Rachel Laura (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-23T17:29:37Z.
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