Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mamma...

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Main Authors: Chen, Walter W. (Contributor), Marjanovic, Nemanja (Contributor), Zoncu, Roberto (Contributor), Katajisto, Pekka (Author), Dohla, Julia (Author), Chaffer, Christine L. (Author), Pentinmikko, Nalle (Author), Iqbal, Sharif (Author), Weinberg, Robert A (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Weinberg, Robert A. (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-04-23T17:48:20Z.
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