mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

mTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this function of mTORC2 is critical for cancer progression is unknown. Here, we show that transformed human prostate epithelial cells lacking PTEN requir...

Full description

Bibliographic Details
Main Authors: Guertin, David A. (Contributor), Stevens, Deanna M. (Author), Saitoh, Maki (Contributor), Kinkel, Stephanie (Contributor), Crosby, Katherine (Author), Sheen, Joon-Ho (Contributor), Mullholland, David J. (Author), Magnuson, Mark A. (Author), Wu, Hong (Author), Sabatini, David (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Stevens, Deanna M. (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2015-04-24T18:55:24Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items