Target specificity of the CRISPR-Cas9 system
The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effect...
| Main Authors: | , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Springer-Verlag,
2015-04-24T18:55:24Z.
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| Subjects: | |
| Online Access: | Get fulltext |