Excess cholesterol induces mouse egg activation and may cause female infertility

Excess cholesterol induces mouse egg activation and may cause female infertility

The HDL receptor scavenger receptor, class B type I (SR-BI) controls the structure and fate of plasma HDL. Female SR-BI KO mice are infertile, apparently because of their abnormal cholesterol-enriched HDL particles. We examined the growth and meiotic progression of SR-BI KO oocytes and found that th...

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Main Authors: Yesilaltay, Ayce (Contributor), Dokshin, Gregoriy A. (Contributor), Busso, Dolores (Author), Wang, Li (Contributor), Galiani, Dalia (Author), Vasile, Eliza (Contributor), Quilaqueo, Linda (Author), Orellana, Juan Andrés (Author), Shalgi, Ruth (Author), Dekel, Nava (Author), Albertini, David F. (Author), Rigotti, Attilio (Author), Krieger, Monty (Contributor), Walzer, Dalia F. (Contributor), Page, David C (Author), Chavarria, Tony E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Program in Comparative Media Studies/Writing (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Chavarria, Tony E. (Contributor), Page, David C. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-05-11T14:19:30Z.
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