Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis

Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis

Transforming growth factor-β1 (TGF-β1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which transmit TGF-β1 signal for growth inhibition from the TG...

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Bibliographic Details
Main Authors: Yamamura, Yasuko (Author), Hua, Xianxin (Author), Bergelson, Svetlana (Author), Lodish, Harvey F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lodish, Harvey F. (Contributor)
Format: Article
Language:English
Published: Hindawi Publishing Corporation, 2015-06-09T13:37:50Z.
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