Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis

• Main Authors: Yamamura, Yasuko (Author), Hua, Xianxin (Author), Bergelson, Svetlana (Author), Lodish, Harvey F (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lodish, Harvey F. (Contributor)
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation, 2015-06-09T13:37:50Z.
• Subjects: Article
• Online Access: Get fulltext

Transforming growth factor-β1 (TGF-β1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which transmit TGF-β1 signal for growth inhibition from the TGF-β receptors to the nucleus (1, 2). However, their roles are unclear in the induction of apoptosis. Our results show here that both Smad and AP-1 complexes play a critical role in TGF-β1 signaling for apoptosis.
National Institutes of Health (U.S.) (Grant CA63260)