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01351 am a22002293u 4500 |
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97234 |
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|a dc
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|a Yamamura, Yasuko
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Whitehead Institute for Biomedical Research
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|a Lodish, Harvey F.
|e contributor
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|a Hua, Xianxin
|e author
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|a Bergelson, Svetlana
|e author
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|a Lodish, Harvey F
|e author
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|a Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis
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|b Hindawi Publishing Corporation,
|c 2015-06-09T13:37:50Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/97234
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|a Transforming growth factor-β1 (TGF-β1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which transmit TGF-β1 signal for growth inhibition from the TGF-β receptors to the nucleus (1, 2). However, their roles are unclear in the induction of apoptosis. Our results show here that both Smad and AP-1 complexes play a critical role in TGF-β1 signaling for apoptosis.
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|a National Institutes of Health (U.S.) (Grant CA63260)
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|a en
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|a Article
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|t The Scientific World JOURNAL
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