Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Background Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. Methods We analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 pe...

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Main Authors: Genovese, Giulio (Author), Kahler, Anna K. (Author), Handsaker, Robert E. (Author), Lindberg, Johan (Author), Rose, Samuel A. (Author), Bakhoum, Samuel F. (Author), Chambert, Kimberly (Author), Mick, Eran (Author), Neale, Benjamin M. (Author), Fromer, Menachem (Author), Purcell, Shaun M. (Author), Svantesson, Oscar (Author), Landen, Mikael (Author), Hoglund, Martin (Author), Lehmann, Soren (Author), Gabriel, Stacey B. (Author), Moran, Jennifer L. (Author), Sullivan, Patrick F. (Author), Sklar, Pamela (Author), Gronberg, Henrik (Author), Hultman, Christina M. (Author), McCarroll, Steven A. (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: New England Journal of Medicine, 2015-06-29T14:56:51Z.
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