Precision cancer mouse models through genome editing with CRISPR-Cas9

Precision cancer mouse models through genome editing with CRISPR-Cas9

The cancer genome is highly complex, with hundreds of point mutations, translocations, and chromosome gains and losses per tumor. To understand the effects of these alterations, precise models are needed. Traditional approaches to the construction of mouse models are time-consuming and laborious, re...

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Bibliographic Details
Main Authors: Mou, Haiwei (Author), Kennedy, Zachary (Author), Yin, Hao (Contributor), Xue, Wen (Author), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2015-06-29T16:44:42Z.
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