An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence on increased PHGDH expression extends beyond p...

Full description

Bibliographic Details
Main Authors: Kini, Mitali (Contributor), Mattaini, Katherine Ruth (Contributor), Davidson, Shawn Michael (Contributor), Fiske, Brian Prescott (Contributor), Vander Heiden, Matthew G. (Contributor), Brignole, Edward J (Author), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Brignole, Edward J. (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2015-06-29T18:42:38Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items