Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all samples. T...
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences (U.S.),
2015-06-30T16:42:20Z.
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| Subjects: | |
| Online Access: | Get fulltext |