Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment

Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment

Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component of various neuropsychiatric disorders; however, the mechanisms regulating PV interneurons remain mostly unknown. Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to function as a major regul...

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Main Authors: Rudenko, Andrii (Contributor), Seo, Jinsoo (Contributor), Hu, Ji (Contributor), Su, Susan C. (Contributor), de Anda, Froylan Calderon (Contributor), Durak, Omer (Contributor), Ericsson, Maria (Author), Carlen, Marie (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2015-08-05T16:09:10Z.
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