Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

Effective tuberculosis (TB) vaccine should target tubercle bacilli with various metabolic states and confer long-term protective immunity. In this study, we constructed a novel multi-stage TB subunit vaccine based on fusion protein ESAT6-Ag85B-MPT64(190-198)-Mtb8.4-HspX (LT69 for short) which combin...

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Main Authors: Niu, Hongxia (Author), Peng, Jinxiu (Author), Bai, Chunxiang (Author), Liu, Xun (Author), Hu, Lina (Author), Luo, Yanping (Author), Wang, Bingxiang (Author), Zhang, Ying (Author), Chen, Jianzhu (Contributor), Yu, Hongjuan (Author), Xian, Qiaoyang (Author), Zhu, Bingdong (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2015-08-20T18:28:32Z.
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