Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release

Synaptotagmin 1 (Syt1) is a synaptic vesicle integral membrane protein that regulates neurotransmitter release by activating fast synchronous fusion and suppressing slower asynchronous release. The cytoplasmic C2 domains of Syt1 interact with SNAREs and plasma membrane phospholipids in a Ca[superscr...

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Bibliographic Details
Main Authors: Littleton, J. Troy (Contributor), Lee, Ji Hye (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), Lee, Jihye (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-09-08T15:14:19Z.
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