Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

Tuberculosis (TB) causes almost 2 million deaths annually, and an increasing number of patients are resistant to existing therapies. Patients who have TB require lengthy chemotherapy, possibly because of poor penetration of antibiotics into granulomas where the bacilli reside. Granulomas are morphol...

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Main Authors: Datta, Meenal (Author), Via, Laura E. (Author), Kamoun, Walid S. (Author), Liu, Chong (Author), Chen, Wei (Author), Seano, Giorgio (Author), Weiner, Danielle M. (Author), Schimel, Daniel (Author), England, Kathleen (Author), Martin, John Daniel (Contributor), Gao, Xing (Author), Xu, Lei (Author), Barry, Clifton E. (Author), Jain, Rakesh K. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-09-08T16:32:28Z.
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