Structure and stability of the lamin A tail domain and HGPS mutant

Structure and stability of the lamin A tail domain and HGPS mutant

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging syndrome caused by the expression and accumulation of a mutant form of lamin A, Δ50 lamin A. As a component of the cell's nucleoskeleton, lamin A plays an important role in the mechanical stabilization of the nuclear envelope and...

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Bibliographic Details
Main Authors: Qin, Zhao (Contributor), Kalinowski, Agnieszka (Author), Dahl, Kris Noel (Author), Buehler, Markus J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering (Contributor), Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics (Contributor), Buehler, Markus J. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-13T17:58:26Z.
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