Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

Amine end-modified poly(β-amino ester)s (PBAEs) have generated interest as efficient, biodegradable polymeric carriers for plasmid DNA (pDNA). For cationic, non-degradable polymers, such as polyethylenimine (PEI), the polymer molecular weight (MW) and molecular weight distribution (MWD) significantl...

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Bibliographic Details
Main Authors: Eltoukhy, Ahmed A. (Contributor), Siegwart, Daniel J. (Contributor), Alabi, Christopher A. (Contributor), Rajan, Jay S. (Contributor), Anderson, Daniel Griffith (Contributor), Langer, Robert S (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-21T16:10:40Z.
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