Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury

Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury

The efficacy of biological therapeutics against cartilage degradation in osteoarthritis is restricted by the limited transport of macromolecules through the dense, avascular extracellular matrix. The availability of biologics to cell surface and matrix targets is limited by steric hindrance of the m...

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Main Authors: Byun, Sangwon (Contributor), Sinskey, Yunna L. (Contributor), Lu, Yihong C. S. (Contributor), Ort, Tatiana (Author), Kavalkovich, Karl (Author), Sivakumar, Pitchumani (Author), Hunziker, Ernst B. (Author), Grodzinsky, Alan J. (Contributor), Frank, Eliot (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-22T14:23:09Z.
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