Transport and binding of tumor necrosis factor-α in articular cartilage depend on its quaternary structure
The effect of tumor necrosis factor-α (TNFα) on cartilage matrix degradation is mediated by its transport and binding within the extracellular matrix (ECM) of the tissue, which mediates availability to cell receptors. Since the bioactive form of TNFα is a homotrimer of monomeric subunits, conversion...
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Bibliographic Details
| Main Authors: |
Byun, Sangwon
(Contributor),
Sinskey, Yunna L.
(Contributor),
Lu, Yihong C. S.
(Contributor),
Frank, Eliot
(Contributor),
Grodzinsky, Alan J
(Author) |
|---|
| Other Authors: |
Massachusetts Institute of Technology. Center for Biomedical Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Biological Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Biology
(Contributor),
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
(Contributor),
Massachusetts Institute of Technology. Department of Mechanical Engineering
(Contributor),
Grodzinsky, Alan J.
(Contributor) |
|---|
| Format: | Article
|
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| Language: | English |
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| Published: |
Elsevier,
2015-10-23T12:00:44Z.
|
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| Subjects: | |
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| Online Access: | Get fulltext
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